Process for the preparation of α-cyanobenzyl esters

ABSTRACT

Novel esters in the form of their stereoisomers and mixtures of stereoisomers of the formula ##STR1## wherein X is selected from the group consisting of fluorine, chlorine and bromine R 1  is selected from the group consisting of ##STR2## Y 1  and Y 2  may both be methyl and when Y 1  is hydrogen, Y 2  is selected from the group consisting of ##STR3## and Y 3  and Y 4  are individually selected from the group consisting of fluorine, bromine and chlorine or the group consisting of hydrogen and methyl, Z is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms, and when Y 2  is ##STR4## R 2  is selected from the group consisting of ##STR5## A is selected from the group consisting of ##STR6## and when Y 2  is -CHBr-CCl 2  Br, R 2  is m-phenoxy-phenyl and when R 1  is R 1  &#39; and Y 2  is ##STR7## the said acid moiety may be in the cis or trans form or mixtures thereof or optically active isomeric form or racemic mixtures thereof and when R 1  is R 1  &#34;, the said acid moiety is optically active isomeric form or racemic mixtures thereof and the compounds may be in one of two diastereoisomeric forms due to the existence of the asymetrical carbon atoms to which X is attached having insecticidal activity and their preparation.

PRIOR APPLICATION

This application is a divisional application of copending, commonly assigned U.S. pat. application Ser. No. 951,184, filed Oct. 13, 1978, now U.S. Pat. No. 4,277,617.

STATE OF THE ART

French Pat. No. 2,185,612 and an article of Thieme [Synthesis International Journal of Methods in Organic Chemistry No. 9 Sept. 1975] describe similar types of compounds.

OBJECTS OF THE INVENTION

It is an object of the invention to provide the novel esters of formula I_(A) and a novel process for their preparation.

It is another object of the invention to provide novel insecticidal compositions and a novel method of combatting insects.

These and other objects and advantages of the invention will become obvious from the following detailed description.

THE INVENTION

The novel esters of α-haloalcohols of the invention are comprised of esters in the form of their stereoisomers and mixtures of stereoisomers of the formula ##STR8## wherein X is selected from the group consisting of fluorine, chlorine and bromine, R₁ is selected from the group consisting of ##STR9## Y₁ and Y₂ may both be methyl and when Y₁ is hydrogen, Y₂ is selected from the group consisting of ##STR10## are individually selected from the group consisting of fluorine, bromine and chlorine or the group consisting of hydrogen and methyl, Z is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms, and when Y₂ is ##STR11## R₂ is selected from the group consisting of ##STR12## A is selected from the group consisting of ##STR13## and when Y₂ is -CHBr-CCl₂ Br, R₂ is m-phenoxy-phenyl and when R₁ is R₁ ' and Y₂ is ##STR14## the said acid moiety may be in the cis or trans form or mixtures thereof or optically active isomeric form or racemic mixtures thereof and when R₁ is R₁ ", the said acid moiety is optically active isomeric form or racemic mixtures thereof and the compounds may be in one of two diastereoisomeric forms due to the existence of the asymetrical carbon atoms to which X is attached.

Among the compounds of formula I_(A) are the stereoisomers of compounds of the formula ##STR15## wherein R₂ and X have the above definition and R is selected from the group consisting of R₁ ", as defined above and ##STR16## wherein Y₁ and Y₂ are both methyl or Y₁ is hydrogen and Y₂ is ##STR17## and Y₃ and Y₄ are individually selected from the group consisting of fluorine, chlorine and bromine or from the group consisting of hydrogen and methyl, so that when Y₂ is not methyl, the acid moiety have cis or trans structure or a mixture thereof or optically active isomers or a racemic mixture.

The compounds of formula I_(A) may exist in numerous stereoisomeric forms. When Y₁ is hydrogen and Y₂ is ##STR18## the R₁ group possesses asymetric carbon atoms in the 1- and 3-positions of the cyclopropane ring and the corresponding carboxylic acids may have cis or trans structure or mixtures thereof or be optically active isomers or racemates. When Y₃ and Y₄ are different, there further exists an (E) and (Z) isomer about the double bond.

When R₁ " is derived from 2-aryl-2-isopropylacetic acids substituted on the 2-carbon atoms, the 2-carbon atom is asymetrical which causes the existence of 2 enantiomeric forms or a racemate. In addition, the carbon of the compounds of formula I_(A) carrying the X substituted is an asymetric carbon.

It is considered as probable that after the process to prepare the compounds of formula I_(A), wherein R₁ contains one or more asymetrical carbon atoms of absolute well defined configuration, there is an asymetric induction on the carbon atoms carrying the X substituent. However, the said induction obtained is not, in general, total and the central chiral (carrying the X) is not, in general, entirely the (R) structure and not entirely the (S) structure with the results that the product of formula I_(A) is a mixture of 2 diastereoisomers which may be separated into the isomer A and isomer B.

By convention, isomer A is the isomer which is more mobile in thin layer chromatography. According to certain theoretical considerations but without being limited to the exactness of the assignment of chirality which has been deduced, it is plausible to attribute to the A isomer the absolute (S) configuration for the carbon substituted with X.

The asymetric carbon atoms of the ethyl side chain of compounds of formula I_(A) where R₁ is the group in which Y₁ is hydrogen and Y₂ is ##STR19## has for its part the existence of 2 diastereoisomers which can be separated by chromatography, for example.

The compounds of formula I_(A) encompass with the definitions for X, R₁ and R₂ all the compounds arising from the combination an optically active isomer or racemate resulting from the existence of asymetric carbons of the acid R₁ moiety of the molecule with an optically active isomer or racemate of the alcohol moiety ##STR20## The preferred compounds of formula I_(A) include those wherein R' has the definition in which Y₁ is hydrogen and Y₂ is ##STR21## and those wherein R₂ is ##STR22## those wherein X is fluorine, those wherein R₂ is ##STR23## and X is fluorine, bromine or chlorine.

Examples of specific preferred compounds of formula I_(A) are RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate, RS α-fluoro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate, RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate, RS α-chloro-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl-acetate and RS α-chloro-3-phenoxybenzyl 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylate.

The novel process of the invention for the preparation of the compounds of formula I_(A) comprises reacting an acid halide of the formula ##STR24## when X and R₁ have the above definitions with an aldehyde of the formula ##STR25## wherein R₂ has the above definition in the presence of an acid catalyst to form the compound of formula I_(A). To produce the compounds of formula I, the acid halide may have the formula ##STR26## wherein R and X have the above definitions.

The acid bromides and chlorides of formulae II and II_(A) may be effected by classical methods and the fluorides of the said acids are advantageously prepared by the process of Mukaiyama, Chem. Letters (1976), p. 303-306. The acid catalyst used in the condensation reaction is preferably a Lewis acid such as zinc chloride, aluminum chloride or ferric chloride or a protonic acid such as p-toluene sulfonic acid or oleum. The condensation may be effected by simply mixing the reactants and the acid catalyst without a solvent but the presence of an organic solvent is equally useful.

A preferred embodiment of the process to produce compounds of formula I wherein X is fluorine and R₂ is selected from the group consisting of ##STR27## comprises reacting a quaternary ammonium fluoride fixed on a resin with a (Z₁) having a formula selected from the group consisting of ##STR28## subjecting the corresponding fluoride (Z₂) to the action of N-bromosuccinimide in the presence of azoisobutyronitrile to obtain a mixed bromide and fluoride derivative Z₃ of the formula ##STR29## and reacting the latter with an alkali metal salt of the formula ##STR30## wherein R has the above definition and M is an alkali metal ion.

For the preparation of the fluoride (Z₂), a resin of the Amberlite A-26 type is advantageously used which is washed by percolation with an aqueous solution hydroxide solution and then water washed until the wash water is neutral and the resulting wet resin is stirred with an aqueous hydrofluoric acid solution and is then washed with water and dried by washing with organic solvents. The fluorination of the chloride (Z₁) with the said resin is advantageously effected in an organic solvent such as toluene.

The reaction of the fluoride (Z₂) and N-bromosuccinimide in the presence of azoisobutyronitrile is conveniently effected in refluxing carbon tetrachloride. The condensation of the mixed bromide-fluoride (Z₃) with the salt of formula II is preferably effected in an organic solvent such as dimethylformamide.

The novel insecticidal compositions of the invention are comprised of an insecticidally effective amount of at least one compound of formula I and a carrier. The compositions contain 0.01 to 95%, preferably 0.05 to 10%, by weight of the active products. The compositions preferably contain a synergist such as piperonyl butoxide or N-(2-ethylheptyl)-bicyclo (2,2,1)-5-hepten-2,3-dicarboxiimide and may contain one or more other pesticidal agents. The compositions may be in the form of powders, granules, suspensions, emulsions, solutions, aerosol compositions, combustible tapes, coils, or other classically used preparations for the use of compounds of this nature and are useful in the home and agriculture. The preferred compounds of formula I_(A) are those wherein R₂ is ##STR31##

Examples of the inert carriers of the compositions of the invention are a vehicle and/or a nonionic surface active agent to ensure a uniform dispersion of the substance making up the composition. The vehicle may be a liquid such as water, alcohol, hydrocarbons, other organic solvents, or a mineral, animal or vegetable oil or a powdered solid such as talc, clays, silicates, kieselguhr or a combustible solid such as tabu powder (or pyrethrum residue).

The novel insecticidal method of the invention comprises contacting insects with a lethal dose of at least one compound of formula I_(A).

The compounds of formula I_(A) are also useful intermediates for the synthesis of esters possessing remarkable insecticidal properties and it is a further object of the invention to provide a process for the preparation of compounds in stereoismeric form or mixtures thereof of the formula ##STR32## wherein R₁ and R₂ have the same definitions as in formula I_(A) with it being well understood that the existence of the asymetrical carbon atom carrying the CN⁻ carries over into the obtained ester with the stereoisomeric acid defined in a unique fashion, the existence of 2 diastereoisomers (isomers A and B). The process comprises reacting a compound which generates CN⁻ ions with a compound of formula I_(A) to obtain the corresponding compound of formula I_(B) existing in the stereoisomeric forms corresponding to the starting compound of formula I_(A). The compounds of formula I may be used in place of the compounds of formula I_(A) and the compounds of the formula ##STR33## wherein R and R₂ have the above definition, are thus obtained.

Preferably, X is chlorine or fluorine and the condensation reaction is effected in an anhydrous organic solvent selected from the group consisting of acetonitrile and dimethylformamide. The compound generating CN⁻ ions is preferably an alkali metal cyanide such as potassium cyanide or sodium cyanide but equally useful are other cyanide ion generators such as tetraethylammonium cyanide, 1-methyl-1-ethyl-ethanolnitrile and cuprous cyanide. The isomeric mixtures may be separated by known methods.

The process of the invention for the preparation of compounds of I_(B) or I_(C) is particularly useful for preparing RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate starting from RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate; RS α-cyano-3-phenoxy-benzyl 1R, cis, 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate starting from RS α-fluoro-3-phenoxybenzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate; RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate starting from RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate; RS α-cyano-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropylacetate starting from RS α-chloro-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl-acetate; and RS α-cyano-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)cyclopropane-1-carboxylate starting from RS α-chloro or fluoro-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylate.

The many compounds of formula I_(B) are well known for their intense insecticidal activity such as French Pat. No. 2,185,612 and published French application Ser. No. 2,364,884. Especially useful are RS α-cyano-3-phenoxy-benzyl 1R cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate, RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate and RS α-cyano-3-phenoxy-benzyl 1R, trans2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylate.

The process of the invention for the preparation of the compounds of formula I_(A) as well as the process for the compounds of formula I_(B) is a new economical process for access to the compounds of formula I_(B) with the advantages of readily accessible reactants leading to high yields of the compounds of formula I_(B) while avoiding the use of α-cyano-3-phenoxy-benzyl alcohol which is a fragile and delicate compound to handle.

The compounds of formula II are known compounds and among these the acid chlorides of the formula ##STR34## are described in French Pat. No. 2,364,884 which also permits the preparation of the corresponding acids. The other acid halides can be prepared by classical methods starting from the corresponding acids of French Pat. No. 2,364,884.

In the following examples there are described several preferred embodiments to illustrate the invention. However, it is to be understood that the invention is not intended to be limited to the specific embodiments.

EXAMPLE 1 RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

10 mg of fused zinc chloride in the form of a powder were added to a mixture of 6.4 g of 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid [prepared by process of Example 16 of French Pat. No. 2,185,612] and 4 g of m-phenoxy-benzaldehyde and heating and thickening of the medium was noted. The mixture stood for one hour at 20° C. under strict anhydrous conditions to obtain RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

IR Spectrum (chloroform):

Absorption at 1749 cm⁻¹ (C═0)

RMN Spectrum (deuterochloroform):

Peaks at 1.26-1.33 ppm (hydrogens of geminal methyls); at 1.85-2.10 ppm (hydrogens of cyclopropyl); at 6.76-6.90 ppm (ethylenic hydrogen); at 7.0 ppm and 7.66 ppm (hydrogens of aromatic ring and benzyl).

EXAMPLE 2 RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

Using the procedure of Example 1 with 60 mg of ferric chloride and stirring for 4 hours, raw RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate was obtained.

EXAMPLE 3

Using the procedure of Example 1 with 60 mg of p-toluene sulfonic acid and stirring for 20 hours, raw RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate was obtained.

EXAMPLE 4

Using the procedure of Example 1 with a drop of 65% oleum and stirring for one hour, raw RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate was obtained.

EXAMPLE 5 RS α-bromo-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate STEP A: 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid bromide

0.2 ml of pyridine were added to a solution of 18 g of 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid in 60 ml of toluene and then 6 ml of phosphorus tribromide were progressively added thereto. The mixture was stirred at 20° C. for 6 days and was then decanted to separate a dense oil in the lower phase of the reaction mixture. The solvent was distilled under reduced pressure and the residue was rectified to obtain 14 g of 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid bromide with a boiling point of 110° C. at 0.2 mm Hg.

IR Spectrum (chloroform):

Absorption at 1792 cm⁻¹ (COOH)

RMN Spectrum (deuterochloroform):

Peaks at 1.32-1.36 ppm (hydrogens of geminal methyls); at 2.12-2.26-2.40 ppm (1-hydrogen of cyclopropyl); at 2.66-2.80 ppm (3-hydrogen of cyclopropyl); at 6.53-6.66 ppm (ethylenic hydrogen).

STEP B: RS α-bromo-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

5 mg of zinc chloride were added to a mixture of 5.66 g of the product of Step A and 3.11 g of m-phenoxybenzaldehyde after which heat and a thickening of the mixture was noted. The mixture stood for 1 hour at 20° C. under strictly anhydrous conditions to obtain RS α-bromo-3-phenoxybenzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

IR Spectrum (chloroform):

Absorption at 1750 cm⁻¹ (COOH)

RMN Spectrum (deuterochloroform):

Peaks at 1.26-1.33 ppm (hydrogens of geminal methyls); at 1.75-2.16 ppm (hydrogens of cyclopropyl); 6.76-6.88 ppm (ethylenic hydrogen); 7.0-7.75 ppm (hydrogens of phenyl and benzyl).

EXAMPLE 6 RS α-chloro-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

10 mg of zinc chloride were added to a mixture of 6.4 g of 1R, trans 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid chloride and 4 g of m-phenoxy-benzaldehyde and the mixture was stirred for one hour to obtain a solution of RS α-chloro-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 7 RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate

10 mg of zinc chloride were added to a mixture of 4.6 g of 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylic acid chloride and 4 g of m-phenoxy-benzaldehyde and the mixture was stirred for one hour to obtain a solution of RS α-chloro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 8 RS α-chloro-3-phenoxy-benzyl 2,2-dimethyl-3R-(2'-methyl-1'-propenyl)-cyclopropane-1R-carboxylate

10 mg of zinc chloride were added to a mixture of 1.89 g of 2,2-dimethyl-3R-(2'-methyl-1'-propenyl)-cyclopropane-1R-carboxylic acid chloride and 2 g of m-phenoxy-benzaldehyde and the mixture was stirred for 21/2 hours to obtain 3.89 g of raw RS α-chloro-3-phenoxy-benzyl 2,2-dimethyl-3R-(2'-methyl-1'-propenyl)-cyclopropane-1R-carboxylate.

EXAMPLE 9 RS α-chloro-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropylacetate

10 mg of zinc chloride were added to a mixture of 4.7 g of 2-(p-chlorophenyl)-2-isopropyl-acetyl chloride and 4 g of m-phenoxy-benzaldehyde and the mixture was stirred for 3 hours at 20° C. to obtain a solution of RS α-chloro-3-phenoxybenzyl 2-(p-chlorophenyl)-2-isopropyl-acetate.

EXAMPLE 10 RS α-chlorocinnamyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

10 mg of zinc chloride were added to a mixture of 4.84 g of 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid chloride and 2.22 g of cinnamic aldehyde and the mixture was stirred for one hour at 20° C. to obtain 7.06 g of raw RS α-chlorocinnamyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate melting at about 82° C.

EXAMPLE 11 RS α-fluoro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate STEP A: m-phenoxy-benzyl fluoride

Using the procedure of Cainelli et al [Synthesis, 1976, p. 472], 220 g of Amberlite A-26 resin was washed by percolation with 1.5 liters of N aqueous sodium hydroxide and then with water until the wash water was neutral. The wet resin containing OH³¹ groups was stirred for 20 hours at 20° C. in an aqueous N hydrofluoric acid solution and was then vacuum filtered. The resin was washed with water, acetone and then ether and was dried at 50° C. under reduced pressure for 10 hours.

A mixture of 40 g of the said resin, 10.5 g of m-phenoxy benzyl chloride and 150 ml of toluene was heated with sitrring at 100° C. for 20 hours and was then filtered to remove the resin. The filter was washed with methylene chloride and the filtrate was evaporated to dryness under reduced pressure. The residue was rectified to obtain 5.8 g of m-phenoxy-benzyl fluoride boiling at 93° C. at 0.05 mm Hg.

RMN Spectrum (deuterochloroform):

Peaks at 4.91-5.71 ppm (hydrogens of --CH₂ F); at 6.91-7.6 ppm (hydrogens of aromatic ring).

STEP B: 1-bromofluoromethyl-3-phenoxy-benzene

A mixture of 2 g of the product of Step A, 2 g of N-bromosuccinimide, 50 g of azoisobutyronitrile and 20 ml of carbon tetrachloride was refluxed for one hour and was then cooled and filtered. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with petroleum ether (b.p.=35°-75° C.) yielded 1.8 g of 1-bromofluoromethyl-3-phenoxybenzene.

Analysis:

Calculated: %C: 55.54; %H: 3.58; %Br: 28.42; %F: 6.75; Found: %C: 56.1; %H: 3.7; %Br: 28.0; %F: 6.4.

RMN Spectrum (deuterochloroform):

Peaks at 6.43-7.75 ppm (hydrogen of --CHBrF); at 6.91-7.5 ppm (hydrogens of aromatic ring).

STEP C: RS α-fluoro-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

A mixture of 1.19 g of the product of Step B, 1.5 g of sodium 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate and 10 ml of dimethylformamide was stirred at 20° C. for 17 hours and was then poured into a water-ice mixture. The mixture was extracted with benzene and after the usual treatment, the benzene extract was evaporated to dryness under reduced pressure. The raw residue was a mixture of 2-diastereoisomers of RS α-fluoro-3-phenoxybenzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate and was subjected to chromatography over silica gel. Elution with a 95-5 petroleum ether (b.p.=35°-75° C.)-ether mixture yielded 0.530 g of the diastereisomer A melting at 80° C. (more mobile) and 0.700 g of diastereoisomer B melting at 50° C. (less mobile) as well as 0.420 g of a mixture of the 2 isomers for a total yield of 1.65 g of the desired ester.

RMN Spectrum (deuterochloroform): isomer A

Peaks at 1.32-1.35 ppm (hydrogens of geminal methyls); 6.8-7.71 ppm (hydrogen of carbon attached to fluorine); at 1.85-2.1 ppm (hydrogens of cyclopropyl); at 6.66-7.83 ppm (hydrogens of aromatic ring).

Circular dichroism (dioxane): isomer A

Δε=+0.30 at 284 nm (maximum)

Δε=+0.25 at 278 nm (maximum)

Δε=+10.8 at 215 nm (maximum)

RMN Spectrum (deuterochloroform): isomer B

Peaks at 1.28 ppm (hydrogens of geminal methyls); 6.8-7.7 ppm (hydrogen of carbon attached to fluorine); 1.86-2.25 ppm (hydrogens of cyclopropyl); 6.8-7.6 ppm (hydrogens of aromatic ring).

Circular dichroism (dioxane): isomer B

Δε=-0.77 at 277 nm (maximum)

Δε=-12.5 at 227 nm (maximum)

Δε=+7.23 at 207 nm (maximum)

The same compound was also prepared by reacting 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylic acid fluoride and m-phenoxy-benzaldehyde in the presence of zinc chloride.

EXAMPLE 12 RS α-chloro-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylate

A mixture of 8 g of 3-phenoxy-benzaldehyde and 15.5 g of 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylic acid chloride was warmed to obtain a homogeneous liquid and the mixture was cooled to 20° C. 0.150 g of anhydrous zinc chloride were added thereto and the mixture was stirred at 20° C. for 17 hours to obtain raw RS α-chloro-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylate whose IR spectrum showed an absorption at 1750 cm⁻¹ (carbonyl) and whose RMN Spectrum showed the absence of an aldehydic proton.

EXAMPLE 13 RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

0.8 g of anhydrous potassium cyanide was added to a solution of 5.5 g of the raw product of Example 1 in 150 ml of anhydrous acetonitrile and the mixture was stirred at 20° C. for 17 hours. Water was added thereto and the mixture was extracted with benzene. The benzene extracts were treated in the usual manner to obtain 5.6 g of raw product which was chromatographed over silica gel. Elution with a 9-1 petroleum ether (b.p.=35°-75° C.)-ether mixture yielded 4.3 g of RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 14 RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

Using the procedure of Example 13, the α-bromo compound of Example 5 was reacted to obtain RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 15 RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

0.2 g of potassium cyanide was added to a solution of 1.17 g of the raw α-fluoride compound of Example 11 in 15 ml of acetonitrile and the mixture was stirred at 20° C. for 17 hours. The residue was chromatographed over silica gel and was eluted with a 9-1 petroleum ether-ether mixture to obtain 1 g of RS α-cyano-3-phenoxy-benzyl 1R, cis, 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 16 RS α-cyano-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

90 ml of acetonitrile were added to the solution obtained in Example 6 and 1.5 g of potassium cyanide were added thereto. The mixture was stirred for 16 hours and water was added thereto after which the mixture was extracted with benzene. The benzene extracts was treated in the usual manner and were evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and elution with a 6-4 benzene-cyclohexane mixture yielded 7.5 g of RS α-cyano-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 17 RS α-cyano-3-phenoxy-benzyl-1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate

1.5 g of potassium cyanide were added to a mixture of 80 ml of acetonitrile and the solution of product obtained in Example 7 and the mixture was stirred for 17 hours after which water was added thereto. The mixture was extracted with benzene and the benzene extracts were treated in the usual manner and were evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and elution with a 6-4 benzene-cyclohexane mixture yieled 6.4 g of RS α-cyano-3-phenoxy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropane-1-carboxylate.

EXAMPLE 18 RS α-cyano-3-phenoxy-benzyl 2,2-dimethyl-3R-(2'-methyl-1'-propenyl)-cyclopropane-1R-carboxylate

1.1 g of potassium cyanide were added to a solution of 50 ml of acetonitrile and 3.09 g of the raw product of Example 8 and the mixture was stirred for 48 hours and was poured into ice water. The mixture was extracted with benzene and the benzene extracts were dried over magnesium silicate, filtered and evaporated to dryness under reduced pressure. The 3.96 g of residue was chromatographed over silica gel and was eluted with a 9-1 cyclohexane-ethyl acetate mixture to obtain 0.48 g of RS α-cyano-3-phenoxy-benzyl 2,2-dimethyl-3R-(2'-methyl-1'-propenyl)-cyclopropane-1R-carboxylate.

IR Spectrum (chloroform):

Absorption at 1733 cm⁻¹ (COOH); at 1487-1587 cm⁻¹ (aromatic ring).

EXAMPLE 19 RS α-cyano-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl acetate

1.5 g of potassium cyanide were added to a mixture of 80 ml of acetonitrile and the solution obtained in Example 9 and the mixture was stirred at 20° C. for 72 hours. Ether was added to the mixture which was then filtered to remove insolubles. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a 95-5 cyclohexane-acetone mixture yielded 6.5 g of RS α-cyano-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl-acetate.

EXAMPLE 20 RS α-cyano-cinnamyl 1R, cis, 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate

1.5 g of potassium cyanide were added to a mixture of 75 ml of acetonitrile and 4.76 g of the raw product of Example 10 and the mixture was stirred for 42 hours and was poured into ice water. The mixture was extracted with benzene and the benzene extracts were washed with water, dried over magnesium sulfate and filtered. The filtrate was evaporated to dryness under reduced pressure and the 5.3 g of resin was chromatographed over silica gel. Elution with 9-1 cyclohexane-ethyl acetate mixture yielded 1.76 g of RS α-cyanocinnamyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate.

Analysis: C₁₈ H₁₇ Br₂ NO₂ ; molecular weight=439.16

Calculated: %C; 49.2; %H; 3.9; %Br; 36.4; %N; 3.2;

Found: %C; 49.5; %H; 4.1; %Br; 34.2; %N; 2.8.

EXAMPLE 21 (S) and (R) α-cyano-3-phenoxy-benzyl esters of 1R, trans 2,2dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane -1-carboxylic acid

17.8 g of the raw product of Example 12 were dissolved in 200 ml of benzene and 2 g of potassium cyanide were added to the solution which then stood at 20° C. for 50 hours with stirring. The mixture was diluted with water and was extracted with benzene. The benzene extracts were evaporated to dryness and the residue was chromatographed over silica gel. Elution with a 1-9 ether-petroleum ether mixture yielded 0.63 g of (R) α-cyano-3-phenoxy-benzyl 1R, trans 2,2-dimethyl-3-(1',2'-dibromo-2',2'-dichloroethyl)-cyclopropane-1-carboxylate (compound A) and then 1.13 g of the corresponding (S) α-cyano-3-phenoxy-benzyl ester (compound B).

RMN Spectrum (deuterochloroform): Compound A

Peaks at 1.32-1.35 ppm (hydrogens of 2-methyls of cyclopropyl); at 4.18 and 4.35 ppm and 4.35 and 4.53 ppm (1'-hydrogen of ethyl side chain); at 6.37 ppm (hydrogen on carbon attached to -CN).

RMN Spectrum (deuterochloroform): Compound B

Peaks at 1.2-1.25-1.32 ppm (hydrogens of 2-methyls of cyclopropyl); at 4.21-4.38-4.37-4.53 ppm (1'-proton of ethyl side chain); at 6.42 ppm (benzyl proton).

EXAMPLE 22

An emulsifiable insecticidal concentrate was prepared by intimately admixing 1 g of the A isomer of α-fluoro-3-phenxoy-benzyl 1R, cis 2,2-dimethyl-3-(2',2'-dibromovinyl) -cyclopropane-1-carboxylate, 20 g of Tween 80 (polyoxyethylene sorbitan mono-oleate), 0.1 g of Topanol A (phenolic antioxidant) and 78.9 g of xylene.

INSECTICIDAL ACTIVITY

The insecticidal activity of the B isomer of α-fluoro-3-phenoxy-benzyl 1R, cis, 2,2-dimethyl-3-(2',2'-dibromovinyl)-cyclopropane-1-carboxylate was determined on house flies. Both sexes of the house fly received a topical application of 1 μl of an acetone solution of the test product on their dorsal thorax. 50 insects were used for each test and the number of dead insects was determined 24 hours after the treatment. One series of tests used the B isomer alone and a second series of tests used a 10-1 piperonyl butoxide-isomer B synergistic mixture. The DL₅₀ (dose which killed 50% of the insects) was determined to be 9.2 ng/insect for isomer B alone and 3.13 ng/insect for the synergistic mixture.

Various modifications of the products and processes of the invention may be made without departing from the spirit or scope thereof and it is to be understood that the invention is to be limited only as defined in the appended claims. 

We claim:
 1. A process for the preparation of a compound of the formula ##STR35## wherein R₁ is ##STR36## Y₁ and Y₂ may both be methyl or when Y₁ is hydrogen, Y₂ is selected from the group consisting of ##STR37## and Y₃ and Y₄ are individually selected from the group consisting of fluorine, bromine, chlorine, or the group consisting of hydrogen and methyl, Z is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms, and when Y₁ and Y₂ are methyl or when Y₁ is hydrogen and Y₂ is ##STR38## R₂ is selected from the group consisting of ##STR39## A- is selected from the group consisting of ##STR40## and when Y₁ is hydrogen and Y₂ is --CHBr--CCl₂ Br, R₂ is m-phenoxyphenyl, the said acid moiety may be in the cis or trans form or mixtures thereof or optically active isomeric form or racemic mixtures thereof, comprising reacting in an anhydrous medium an acid halide of the formula ##STR41## wherein Y₁ and Y₂ and Z have the above definition and X is selected from the group consisting of fluorine, chlorine and bromine with an aldehyde of the formula ##STR42## wherein R₂ has the above definition in the presence of an acid catalyst to obtain a compound of the formula ##STR43## that may be in one of two diastereoisomeric forms due to the existence of the asymetrical carbon atoms to which X is attached and reacting the obtained compound with a compound which generates CN⁻ ions to obtain the corresponding above compound.
 2. The process of claim 1 wherein the acid catalyst is a Lewis acid selected from the group consisting of zinc chloride, aluminum chloride and ferric chloride.
 3. The process of claim 1 wherein the acid catalyst is a protonic acid selected from the group consisting of p-toluene sulfonic acid and oleum.
 4. The process of claim 1 wherein X is selected from the group consisting of fluorine and chlorine.
 5. The process of claim 1 wherein the condensation with the cyanide ion generating agent is effected in an anhydrous organic solvent.
 6. The process of claim 5 wherein the solvent is selected from the group consisting of acetonitrile and dimethylformamide.
 7. The process of claim 1 wherein the cyanide ion generator is an alkali metal cyanide. 